The Hospital, with a clear plateresque style, was built at the beginning of the 16th century by cardinal Pedro González de Mendoza as a single gathering point for all hospitals of Toledo.

It currently hosts the Museum of Santa Cruz, where different canvases painted by El Greco are exhibited, among which we can highlight "La Asunción de la Virgen", as well as other works from different artists and interesting archeological objects and objets d'art.